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Research Article

Coating with a Modular Bone Morphogenetic Peptide Promotes Healing of a Bone-Implant Gap in an Ovine Model

  • Yan Lu mail,

    luy@svm.vetmed.wisc.edu (YL); wlmurphy@wisc.edu (WLM)

    Affiliations: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Jae Sung Lee,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Brett Nemke,

    Affiliation: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America

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  • Ben K. Graf,

    Affiliation: Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Kevin Royalty,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Richard Illgen III,

    Affiliation: Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Ray Vanderby Jr,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Mark D. Markel,

    Affiliations: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • William L. Murphy mail

    luy@svm.vetmed.wisc.edu (YL); wlmurphy@wisc.edu (WLM)

    Affiliations: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America, Pharmacology, University of Wisconsin, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Published: November 21, 2012
  • DOI: 10.1371/journal.pone.0050378

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