Enterohemorrhagic Escherichia coli Specific Enterohemolysin Induced IL-1β in Human Macrophages and EHEC-Induced IL-1β Required Activation of NLRP3 Inflammasome

• Xiaoai Zhang ,

  Contributed equally to this work with: Xiaoai Zhang, Yuli Cheng

  Affiliations National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China, Beijing Center for Disease Prevention and Control, Beijing, China

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• Yuli Cheng ,

  Contributed equally to this work with: Xiaoai Zhang, Yuli Cheng

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Yanwen Xiong,

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Changyun Ye,

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Han Zheng,

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Hui Sun,

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Hongqing Zhao,

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Zhihong Ren ,

  * E-mail: renzhihong@icdc.cn (ZR); xujianguo@icdc.cn (JX)

  ¶These authors also contributed equally to this work.

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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• Jianguo Xu

  * E-mail: renzhihong@icdc.cn (ZR); xujianguo@icdc.cn (JX)

  ¶These authors also contributed equally to this work.

  Affiliation National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Changping, Beijing, China

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