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Research Article

Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

  • Hong Zhao equal contributor,

    equal contributor Contributed equally to this work with: Hong Zhao, Qinshan Li

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Qinshan Li equal contributor,

    equal contributor Contributed equally to this work with: Hong Zhao, Qinshan Li

    Affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jian Wang,

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Xianwei Su,

    Affiliation: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

    X
  • Ka Man Ng,

    Affiliation: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

    X
  • Tian Qiu,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Ling Shan,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Yun Ling,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Linfang Wang,

    Affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jianqiang Cai mail,

    jmying@hotmail.com (JY); caijianqiang188@sina.com (JC)

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jianming Ying mail

    jmying@hotmail.com (JY); caijianqiang188@sina.com (JC)

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Published: November 13, 2012
  • DOI: 10.1371/journal.pone.0049683

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