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The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

  • Xin Zheng equal contributor,

    equal contributor Contributed equally to this work with: Xin Zheng, Natalia B. Rumie Vittar, Xiaohong Gai

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Natalia B. Rumie Vittar equal contributor,

    equal contributor Contributed equally to this work with: Xin Zheng, Natalia B. Rumie Vittar, Xiaohong Gai

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Xiaohong Gai equal contributor,

    equal contributor Contributed equally to this work with: Xin Zheng, Natalia B. Rumie Vittar, Xiaohong Gai

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Maite G. Fernandez-Barrena,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Catherine D. Moser,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Chunling Hu,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Luciana L. Almada,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Angela L. McCleary-Wheeler,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Sherine F. Elsawa,

    Affiliations: Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois, United States of America

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  • Anne M. Vrabel,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Abdirashid M. Shire,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Andrea Comba,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Snorri S. Thorgeirsson,

    Affiliation: Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Youngsoo Kim,

    Affiliation: Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

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  • Qingguang Liu,

    Affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

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  • Martin E. Fernandez-Zapico,

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Lewis R. Roberts mail

    roberts.lewis@mayo.edu

    Affiliations: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Published: November 19, 2012
  • DOI: 10.1371/journal.pone.0049581

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