Advertisement
Research Article

Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

  • Marie-José C. van Lierop equal contributor mail,

    equal contributor Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema

    mariejose.vanlierop@merck.com

    Affiliation: Department of Immune Therapeutics, MSD, Oss, The Netherlands

    X
  • Wynand Alkema equal contributor,

    equal contributor Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema

    Affiliation: Department of Molecular Design and Informatics, MSD, Oss, The Netherlands

    X
  • Anke J. Laskewitz,

    Affiliation: Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands

    X
  • Rein Dijkema,

    Affiliation: Molecular Pharmacology Department, MSD, Oss, The Netherlands

    X
  • Hans M. van der Maaden,

    Affiliation: Molecular Pharmacology Department, MSD, Oss, The Netherlands

    X
  • Martin J. Smit,

    Affiliation: Molecular Pharmacology Department, MSD, Oss, The Netherlands

    X
  • Ralf Plate,

    Affiliation: Medicinal Chemistry Department, MSD, Oss, The Netherlands

    X
  • Paolo G. M. Conti,

    Affiliation: Medicinal Chemistry Department, MSD, Oss, The Netherlands

    X
  • Christan G. J. M. Jans,

    Affiliation: Medicinal Chemistry Department, MSD, Oss, The Netherlands

    X
  • C. Marco Timmers,

    Affiliation: Women's Health Department, MSD, Oss, The Netherlands

    X
  • Constant A. A. van Boeckel,

    Affiliation: Medicinal Chemistry Department, MSD, Oss, The Netherlands

    X
  • Scott J. Lusher,

    Affiliation: Department of Molecular Design and Informatics, MSD, Oss, The Netherlands

    X
  • Ross McGuire,

    Affiliation: Department of Molecular Design and Informatics, MSD, Oss, The Netherlands

    X
  • Rene C. van Schaik,

    Affiliation: Department of Molecular Design and Informatics, MSD, Oss, The Netherlands

    X
  • Jacob de Vlieg,

    Affiliation: Department of Molecular Design and Informatics, MSD, Oss, The Netherlands

    X
  • Ruben L. Smeets,

    Affiliation: Department of Immune Therapeutics, MSD, Oss, The Netherlands

    X
  • Claudia L. Hofstra,

    Affiliation: Department of Immune Therapeutics, MSD, Oss, The Netherlands

    X
  • Annemieke M. H. Boots,

    Affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands

    X
  • Marcel van Duin,

    Affiliation: Women's Health Department, MSD, Oss, The Netherlands

    X
  • Benno A. Ingelse,

    Affiliation: Toxicology and Drug Disposition, MSD, Oss, The Netherlands

    X
  • Willem G. E. J. Schoonen,

    Affiliation: Toxicology and Drug Disposition, MSD, Oss, The Netherlands

    X
  • Aldo Grefhorst,

    Affiliation: Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands

    X
  • Theo H. van Dijk,

    Affiliation: Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands

    X
  • Folkert Kuipers,

    Affiliations: Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands

    X
  • Wim H. A. Dokter

    Affiliation: Department of Immune Therapeutics, MSD, Oss, The Netherlands

    X
  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0048385

Reader Comments (0)

Post a new comment on this article