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Research Article

Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome

  • Kathryn T. Hall mail,

    kthall@bidmc.harvard.edu

    Affiliations: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Anthony J. Lembo,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Irving Kirsch,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, School of Psychology, University of Plymouth, Devon, United Kingdom

    X
  • Dimitrios C. Ziogas,

    Affiliation: Department of Internal Medicine, University of Athens, Athens, Greece

    X
  • Jeffrey Douaiher,

    Affiliation: Department of Surgery, Johns Hopkins, Baltimore, Maryland, United States of America

    X
  • Karin B. Jensen,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lisa A. Conboy,

    Affiliation: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • John M. Kelley,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Endicott College, Beverly, Massachusetts, United States of America

    X
  • Efi Kokkotou,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ted J. Kaptchuk

    Affiliations: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: October 23, 2012
  • DOI: 10.1371/journal.pone.0048135

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