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Research Article

Measurements of CFTR-Mediated Cl Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis

  • Marisa Sousa equal contributor,

    equal contributor Contributed equally to this work with: Marisa Sousa, Maria F. Servidoni

    Affiliations: BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; Faculty of Sciences, University of Lisboa, Lisboa, Portugal, Department of Genetics - National Institute of Health, Lisboa, Portugal

    X
  • Maria F. Servidoni equal contributor,

    equal contributor Contributed equally to this work with: Marisa Sousa, Maria F. Servidoni

    Affiliations: Gastrocentro - Endoscopy Unit - State University of Campinas, Campinas, Brazil, Pediatrics Department - State University of Campinas, Campinas, Brazil

    X
  • Adriana M. Vinagre,

    Affiliation: Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil

    X
  • Anabela S. Ramalho,

    Affiliations: BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; Faculty of Sciences, University of Lisboa, Lisboa, Portugal, Department of Genetics - National Institute of Health, Lisboa, Portugal

    X
  • Luciana C. Bonadia,

    Affiliation: Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil

    X
  • Verónica Felício,

    Affiliation: BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; Faculty of Sciences, University of Lisboa, Lisboa, Portugal

    X
  • Maria A. Ribeiro,

    Affiliation: CIPED - Research Center in Pediatrics - State University of Campinas, Campinas, Brazil

    X
  • Inna Uliyakina,

    Affiliations: BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; Faculty of Sciences, University of Lisboa, Lisboa, Portugal, Department of Genetics - National Institute of Health, Lisboa, Portugal

    X
  • Fernando A. Marson,

    Affiliation: Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil

    X
  • Arthur Kmit,

    Affiliation: Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil

    X
  • Silvia R. Cardoso,

    Affiliations: Pediatrics Department - State University of Campinas, Campinas, Brazil, Endoscopy Unit – University Hospital of Campinas, Campinas, Brazil

    X
  • José D. Ribeiro,

    Affiliations: Pediatrics Department - State University of Campinas, Campinas, Brazil, Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil, CIPED - Research Center in Pediatrics - State University of Campinas, Campinas, Brazil

    X
  • Carmen S. Bertuzzo,

    Affiliation: Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil

    X
  • Lisete Sousa,

    Affiliation: CEAUL - Center of Statistics and Applications of the University of Lisboa; Department of Statistics and Operation Research, Faculty of Sciences, University of Lisboa, Lisboa, Portugal

    X
  • Karl Kunzelmann,

    Affiliation: Institut für Physiologie – University of Regensburg, Regensburg, Germany

    X
  • Antônio F. Ribeiro,

    Affiliations: Pediatrics Department - State University of Campinas, Campinas, Brazil, Faculty of Medical Sciences - State University of Campinas, Campinas, Brazil, CIPED - Research Center in Pediatrics - State University of Campinas, Campinas, Brazil

    X
  • Margarida D. Amaral mail

    mdamaral@fc.ul.pt

    Affiliations: BioFIG - Centre for Biodiversity, Functional and Integrative Genomics; Faculty of Sciences, University of Lisboa, Lisboa, Portugal, Department of Genetics - National Institute of Health, Lisboa, Portugal

    X
  • Published: October 17, 2012
  • DOI: 10.1371/journal.pone.0047708

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