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Research Article

Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells

  • Yong-Qiang Liu equal contributor,

    equal contributor Contributed equally to this work with: Yong-Qiang Liu, Xin Cheng

    Affiliations: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Graduate University of the Chinese Academy of Sciences, Beijing, China

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  • Xin Cheng equal contributor,

    equal contributor Contributed equally to this work with: Yong-Qiang Liu, Xin Cheng

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Liang-Xia Guo,

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Chan Mao,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Yi-Jie Chen,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Hai-Xia Liu,

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Qi-Cai Xiao,

    Affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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  • Sheng Jiang,

    Affiliation: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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  • Zhu-Jun Yao mail,

    gbzhou@ioz.ac.cn (GBZ); yaoz@nju.edu.cn (YQL)

    Affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

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  • Guang-Biao Zhou mail

    gbzhou@ioz.ac.cn (GBZ); yaoz@nju.edu.cn (YQL)

    Affiliation: Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0047049

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