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Research Article

Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements

  • Bjorn T. Adalsteinsson,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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  • Haukur Gudnason,

    Affiliation: Icelandic Heart Association, Kopavogur, Iceland

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  • Thor Aspelund,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Lenore J. Launer,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Gudny Eiriksdottir,

    Affiliation: Icelandic Heart Association, Kopavogur, Iceland

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  • Albert V. Smith,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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  • Vilmundur Gudnason mail

    v.gudnason@hjarta.is

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0046705

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