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Research Article

A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors

  • Yuting Yao equal contributor,

    equal contributor Contributed equally to this work with: Yuting Yao, Li Wang

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Li Wang equal contributor,

    equal contributor Contributed equally to this work with: Yuting Yao, Li Wang

    Affiliation: Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • He Zhang,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, California, United States of America

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  • Haibo Wang,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Xiaoping Zhao,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Yidan Zhang,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Leilei Zhang,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Xianqun Fan,

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

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  • Guanxiang Qian mail,

    jifan@stanford.edu (J-FH); geshengfang@sjtu.edu.cn (SG); geshengfang@sjtu.edu.cn (SG); qiangx@shsmu.edu.cn (JH)

    Affiliation: Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

    These authors also contributed equally to this work.

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  • Ji-Fan Hu mail,

    jifan@stanford.edu (J-FH); geshengfang@sjtu.edu.cn (SG); geshengfang@sjtu.edu.cn (SG); qiangx@shsmu.edu.cn (JH)

    Affiliation: VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, California, United States of America

    These authors also contributed equally to this work.

    X
  • Shengfang Ge mail

    jifan@stanford.edu (J-FH); geshengfang@sjtu.edu.cn (SG); geshengfang@sjtu.edu.cn (SG); qiangx@shsmu.edu.cn (JH)

    Affiliations: Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

    These authors also contributed equally to this work.

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046627

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