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Research Article

Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese

  • Shusuke Akamatsu,

    Affiliations: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan, Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Atsushi Takahashi,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Ryo Takata,

    Affiliations: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan, Department of Urology, Iwate Medical University, Morioka, Japan

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  • Michiaki Kubo,

    Affiliation: Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Takahiro Inoue,

    Affiliation: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Takashi Morizono,

    Affiliation: Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan

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  • Naoyuki Kamatani,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peggy Wan,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Gary K. Chen,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, Cancer Research Centre, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Laurence N. Kolonel,

    Affiliation: Epidemiology Program, Cancer Research Centre, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Tomoaki Fujioka,

    Affiliation: Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Tomonori Habuchi,

    Affiliation: Department of Urology, Akita University School of Medicine, Akita, Japan

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  • Yusuke Nakamura,

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan

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  • Osamu Ogawa,

    Affiliation: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Hidewaki Nakagawa mail

    hidewaki@ims.u-tokyo.ac.jp

    Affiliation: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0046454

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