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Research Article

Lovastatin Induces Multiple Stress Pathways Including LKB1/AMPK Activation That Regulate Its Cytotoxic Effects in Squamous Cell Carcinoma Cells

  • Laurie Ma,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Nima Niknejad,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Ivan Gorn-Hondermann,

    Affiliation: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada

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  • Khalil Dayekh,

    Affiliations: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada, The Faculty of Medicine and the Department of Biochemistry, University of Ottawa, Ontario, Canada

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  • Jim Dimitroulakos mail

    jdimitroulakos@ohri.ca

    Affiliations: Centre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ontario, Canada, The Faculty of Medicine and the Department of Biochemistry, University of Ottawa, Ontario, Canada

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0046055

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