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Research Article

Aquaporin-1 Translocation and Degradation Mediates the Water Transportation Mechanism of Acetazolamide

  • Jianzhao Zhang equal contributor,

    equal contributor Contributed equally to this work with: Jianzhao Zhang, Yu An

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Yu An equal contributor,

    equal contributor Contributed equally to this work with: Jianzhao Zhang, Yu An

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Junwei Gao,

    Affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    X
  • Jing Han,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Xueyang Pan,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Yan Pan,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

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  • Lu Tie,

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Xuejun Li mail

    lixj@bjmu.edu.cn

    Affiliations: State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, Institute of Systems Biomedicine, Peking University, Beijing, China

    X
  • Published: September 21, 2012
  • DOI: 10.1371/journal.pone.0045976

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