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Research Article

Development of a Non-Invasive Method, Multiplex Methylation Specific PCR (MMSP), for Early Diagnosis of Nasopharyngeal Carcinoma

  • Zhe Zhang equal contributor,

    equal contributor Contributed equally to this work with: Zhe Zhang, Di Sun

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Di Sun equal contributor,

    equal contributor Contributed equally to this work with: Zhe Zhang, Di Sun

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Susanna Hilda Hutajulu,

    Affiliation: Molecular Biology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

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  • Imran Nawaz,

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Do Nguyen Van,

    Affiliations: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden, Department of Immunology and Pathophysiology, Hanoi Medical University (HMU), Dongda, Hanoi, Vietnam

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  • Guangwu Huang,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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  • Sofia M. Haryana,

    Affiliation: Molecular Biology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

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  • Jaap M. Middeldorp,

    Affiliation: Department of Pathology, VU Medical Center, Amsterdam, The Netherlands

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  • Ingemar Ernberg,

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Li-Fu Hu mail

    lifu.hu@ki.se

    Affiliation: Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

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  • Published: November 05, 2012
  • DOI: 10.1371/journal.pone.0045908

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