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Research Article

PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model

  • Horng-Tay Tzeng,

    Affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Hwei-Fang Tsai,

    Affiliations: Department of Internal Medicine, Taipei Medical University, Shuang Ho Hospital, Taipei, Taiwan, Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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  • Hsiu-Jung Liao,

    Affiliation: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Yi-Jiun Lin,

    Affiliation: Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Lieping Chen,

    Affiliation: Cancer Immunology Program at Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Pei-Jer Chen,

    Affiliations: Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Ping-Ning Hsu mail

    phsu8635@ntu.edu.tw

    Affiliations: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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  • Published: June 22, 2012
  • DOI: 10.1371/journal.pone.0039179

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