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Research Article

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

  • Beatriz Mothe,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Anuska Llano,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Javier Ibarrondo,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

    Current address: University of California, Los Angeles, Los Angeles, California, United States of America

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  • Jennifer Zamarreño,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Mattia Schiaulini,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Universitat Autònoma de Barcelona, Barcelona, Spain

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  • Cristina Miranda,

    Affiliation: Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Marta Ruiz-Riol,

    Affiliation: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Christoph T. Berger,

    Affiliation: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America

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  • M. José Herrero,

    Affiliation: Department of Immunology, LIRAD-Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Eduard Palou,

    Affiliation: Department of Immunology, LIRAD-Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Montse Plana,

    Affiliation: AIDS Research Group-IDIBAPS, Hospital Clinic, HIVACAT, University of Barcelona, Barcelona, Spain

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  • Morgane Rolland,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: HIV Military Research Program, Rockville, Maryland, United States of America

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  • Ashok Khatri,

    Affiliation: Massachusetts General Hospital, Peptide/Protein Core Facility, Boston, Massachusetts, United States of America

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  • David Heckerman,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • Florencia Pereyra,

    Affiliation: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America

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  • Bruce D. Walker,

    Affiliations: Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • David Weiner,

    Affiliation: University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Roger Paredes,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Bonaventura Clotet,

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Lluita contra la Sida' Foundation, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Barbara K. Felber,

    Affiliation: NCI-Frederick, Frederick, Maryland, United States of America

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  • George N. Pavlakis,

    Affiliation: NCI-Frederick, Frederick, Maryland, United States of America

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  • James I. Mullins,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Christian Brander mail

    cbrander@irsicaixa.es

    Affiliations: IrsiCaixa AIDS Research Institute - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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  • Published: January 04, 2012
  • DOI: 10.1371/journal.pone.0029717

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