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Research Article

Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease

  • Javier Simón-Sánchez equal contributor,

    equal contributor Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski

    Affiliation: Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

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  • Laura L. Kilarski equal contributor,

    equal contributor Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski

    Affiliations: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • Michael A. Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Maria Martinez,

    Affiliations: Inserm, UMR 1043, Toulouse, France, Paul Sabatier University, Toulouse, France

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  • Claudia Schulte,

    Affiliation: Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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  • Peter Holmans,

    Affiliations: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • International Parkinson's Disease Genomics Consortium,

    a Membership of the International Parkinson's Disease Genomics Consortium is provided in the Acknowledgments.

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  • Wellcome Trust Case Control Consortium,

    Affiliation: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom

    b Membership of the Wellcome Trust Case Control Consortium is provided in supporting information.

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  • Thomas Gasser,

    Affiliation: Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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  • John Hardy,

    Affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

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  • Andrew B. Singleton,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nicholas W. Wood,

    Affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom

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  • Alexis Brice,

    Affiliations: Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France, Inserm, U975, Paris, France, Cnrs, UMR 7225, Paris, France

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  • Peter Heutink,

    Affiliation: Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

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  • Nigel Williams mail,

    williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)

    Affiliations: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • Huw R. Morris mail

    williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)

    Affiliations: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • Published: March 12, 2012
  • DOI: 10.1371/journal.pone.0028787

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