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Research Article

Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria

  • Travis J. Riedel,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Lynnette C. Johnson,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • John Knight,

    Affiliation: Division of Urology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Roy R. Hantgan,

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Ross P. Holmes,

    Affiliation: Division of Urology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • W. Todd Lowther mail

    tlowther@wakehealth.edu

    Affiliation: Center for Structural Biology and Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.pone.0026021

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