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Research Article

Network-Guided Analysis of Genes with Altered Somatic Copy Number and Gene Expression Reveals Pathways Commonly Perturbed in Metastatic Melanoma

  • Armand Valsesia,

    Affiliations: Ludwig Institute for Cancer Research, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

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  • Donata Rimoldi,

    Affiliation: Ludwig Institute for Cancer Research, Lausanne, Switzerland

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  • Danielle Martinet,

    Affiliation: Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Mark Ibberson,

    Affiliation: Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Paola Benaglio,

    Affiliation: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

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  • Manfredo Quadroni,

    Affiliation: Protein Analysis Facility, Center for Integrative Genomics, Lausanne, Switzerland

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  • Patrice Waridel,

    Affiliation: Protein Analysis Facility, Center for Integrative Genomics, Lausanne, Switzerland

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  • Muriel Gaillard,

    Affiliation: Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Mireille Pidoux,

    Affiliation: Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Blandine Rapin,

    Affiliation: Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Carlo Rivolta,

    Affiliation: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

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  • Ioannis Xenarios,

    Affiliation: Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Andrew J. G. Simpson,

    Affiliation: Ludwig Institute for Cancer Research, New York, New York, United States of America

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  • Stylianos E. Antonarakis,

    Affiliation: Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland

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  • Jacques S. Beckmann,

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • C. Victor Jongeneel,

    Affiliations: Ludwig Institute for Cancer Research, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Institute for Genomic Biology and National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America

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  • Christian Iseli mail,

    Christian.Iseli@unil.ch (CI); Brian.Stevenson@unil.ch (BJS)

    Affiliations: Ludwig Institute for Cancer Research, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Brian J. Stevenson mail

    Christian.Iseli@unil.ch (CI); Brian.Stevenson@unil.ch (BJS)

    Affiliations: Ludwig Institute for Cancer Research, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Published: April 08, 2011
  • DOI: 10.1371/journal.pone.0018369

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