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Research Article

The Base Excision Repair Pathway Is Required for Efficient Lentivirus Integration

  • Kristine E. Yoder mail,

    yoder.176@osu.edu (KEY); rfishel@osu.edu (RF)

    Affiliation: Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

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  • Amy Espeseth,

    Affiliation: Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Xiao-hong Wang,

    Affiliation: University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America

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  • Qingming Fang,

    Affiliation: University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America

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  • Maria Teresa Russo,

    Affiliation: Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy

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  • R. Stephen Lloyd,

    Affiliation: Center for Research on Occupational and Environmental Toxicology, Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Daria Hazuda,

    Affiliation: Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Robert W. Sobol,

    Affiliations: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Richard Fishel mail

    yoder.176@osu.edu (KEY); rfishel@osu.edu (RF)

    Affiliations: Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, Physics Department, The Ohio State University, Columbus, Ohio, United States of America

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  • Published: March 23, 2011
  • DOI: 10.1371/journal.pone.0017862

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