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Research Article

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

  • A. David Smith equal contributor mail,

    equal contributor Contributed equally to this work with: A. David Smith, Helga Refsum

    david.smith@pharm.ox.ac.uk

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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  • Stephen M. Smith,

    Affiliation: Department of Clinical Neurology, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom

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  • Celeste A. de Jager,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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  • Philippa Whitbread,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

    X
  • Carole Johnston,

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Grzegorz Agacinski,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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  • Abderrahim Oulhaj,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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  • Kevin M. Bradley,

    Affiliation: Department of Radiology and Nuclear Medicine, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom

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  • Robin Jacoby,

    Affiliation: University Department of Psychiatry, University of Oxford, Oxford, United Kingdom

    X
  • Helga Refsum equal contributor

    equal contributor Contributed equally to this work with: A. David Smith, Helga Refsum

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

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  • Published: September 08, 2010
  • DOI: 10.1371/journal.pone.0012244

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