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Research Article

Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

  • Jessica F. Jordão,

    Affiliations: Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Carlos A. Ayala-Grosso,

    Affiliations: Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Unidad de Biología Molecular, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos, Caracas, Venezuela

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  • Kelly Markham,

    Affiliation: Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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  • Yuexi Huang,

    Affiliation: Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada

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  • Rajiv Chopra,

    Affiliations: Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • JoAnne McLaurin,

    Affiliations: Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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  • Kullervo Hynynen equal contributor mail,

    equal contributor Contributed equally to this work with: Kullervo Hynynen, Isabelle Aubert

    khynynen@sri.utoronto.ca (KH); isabelle.aubert@sri.utoronto.ca (IA)

    Affiliations: Imaging, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Isabelle Aubert equal contributor mail

    equal contributor Contributed equally to this work with: Kullervo Hynynen, Isabelle Aubert

    khynynen@sri.utoronto.ca (KH); isabelle.aubert@sri.utoronto.ca (IA)

    Affiliations: Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: May 11, 2010
  • DOI: 10.1371/journal.pone.0010549

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