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Research Article

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

  • Patricia Spilman,

    Affiliation: The Buck Institute for Age Research, Novato, California, United States of America

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  • Natalia Podlutskaya,

    Affiliations: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Matthew J. Hart,

    Affiliation: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Jayanta Debnath,

    Affiliation: Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Olivia Gorostiza,

    Affiliation: The Buck Institute for Age Research, Novato, California, United States of America

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  • Dale Bredesen,

    Affiliation: The Buck Institute for Age Research, Novato, California, United States of America

    X
  • Arlan Richardson,

    Affiliations: The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America

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  • Randy Strong,

    Affiliations: The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America

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  • Veronica Galvan mail

    galvanv@uthscsa.edu

    Affiliations: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Published: April 01, 2010
  • DOI: 10.1371/journal.pone.0009979

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