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Research Article

Time-Resolved and Tissue-Specific Systems Analysis of the Pathogenesis of Insulin Resistance

  • Robert Kleemann mail,

    Robert.Kleemann@tno.nl

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Marjan van Erk,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Lars Verschuren,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands

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  • Anita M. van den Hoek,

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Maud Koek,

    Affiliation: Quality of Life, Analytical Research, TNO, Zeist, The Netherlands

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  • Peter Y. Wielinga,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Annie Jie,

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Linette Pellis,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Ivana Bobeldijk-Pastorova,

    Affiliation: Quality of Life, Analytical Research, TNO, Zeist, The Netherlands

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  • Thomas Kelder,

    Affiliation: Department of Bioinformatics, Maastricht University, Maastricht, The Netherlands

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  • Karin Toet,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Suzan Wopereis,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Nicole Cnubben,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Chris Evelo,

    Affiliation: Department of Bioinformatics, Maastricht University, Maastricht, The Netherlands

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  • Ben van Ommen,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Teake Kooistra

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Published: January 21, 2010
  • DOI: 10.1371/journal.pone.0008817

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