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Research Article

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

  • Erik Kvam,

    Affiliations: Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

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  • Brent L. Nannenga,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Min S. Wang,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Zongjian Jia,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Michael R. Sierks,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Anne Messer mail

    messer@wadsworth.org

    Affiliations: Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

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  • Published: May 28, 2009
  • DOI: 10.1371/journal.pone.0005727

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