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Research Article

Mitochondrial DNA Variants of Respiratory Complex I that Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-Related Macular Degeneration

  • John Paul SanGiovanni equal contributor mail,

    equal contributor Contributed equally to this work with: John Paul SanGiovanni, Dan E. Arking

    jpsangio@post.harvard.edu

    Affiliation: National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Dan E. Arking equal contributor,

    equal contributor Contributed equally to this work with: John Paul SanGiovanni, Dan E. Arking

    Affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Sudha K. Iyengar,

    Affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Michael Elashoff,

    Affiliation: CardioDx, Palo Alto, California, United States of America

    X
  • Traci E. Clemons,

    Affiliation: The EMMES Corp., Rockville, Maryland, United States of America

    X
  • George F. Reed,

    Affiliation: National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Alice K. Henning,

    Affiliation: The EMMES Corp., Rockville, Maryland, United States of America

    X
  • Theru A. Sivakumaran,

    Affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Xuming Xu,

    Affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Andrew DeWan,

    Affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Elvira Agrón,

    Affiliation: National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Elena Rochtchina,

    Affiliation: Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Carolyn M. Sue,

    Affiliation: University of Sydney Kolling Institute for Medical Research, Sydney, Australia

    X
  • Jie Jin Wang,

    Affiliation: Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Paul Mitchell,

    Affiliation: Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia

    X
  • Josephine Hoh,

    Affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America

    X
  • Peter J. Francis,

    Affiliation: Macular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America

    X
  • Michael L. Klein,

    Affiliation: Macular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America

    X
  • Emily Y. Chew,

    Affiliation: National Eye Institute (NEI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Aravinda Chakravarti

    Affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Published: May 12, 2009
  • DOI: 10.1371/journal.pone.0005508

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