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Research Article

A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity

  • Iana Parvanova,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

    Current address: Division of Molecular Pathobiology, Department of Clinical Research and VPH, Vetsuisse Faculty Bern, Bern, Switzerland

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  • Sabrina Epiphanio,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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  • Abdul Fauq,

    Affiliation: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, Florida, United States of America

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  • Todd E. Golde,

    Affiliation: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, Florida, United States of America

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  • Miguel Prudêncio,

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Maria M. Mota mail

    mmota@fm.ul.pt

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Published: April 01, 2009
  • DOI: 10.1371/journal.pone.0005078

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