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Research Article

Quality-Controlled Small-Scale Production of a Well-Defined Bacteriophage Cocktail for Use in Human Clinical Trials

  • Maya Merabishvili,

    Affiliations: Eliava Institute of Bacteriophage, Microbiology and Virology (EIBMV), Tbilisi, Georgia, Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium, Laboratory of Bacteriology Research (LBR), Ghent University Hospital, Ghent, Belgium

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  • Jean-Paul Pirnay mail,

    jean-paul.pirnay@mil.be

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Gilbert Verbeken,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Nina Chanishvili,

    Affiliation: Eliava Institute of Bacteriophage, Microbiology and Virology (EIBMV), Tbilisi, Georgia

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  • Marina Tediashvili,

    Affiliation: Eliava Institute of Bacteriophage, Microbiology and Virology (EIBMV), Tbilisi, Georgia

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  • Nino Lashkhi,

    Affiliation: Eliava Institute of Bacteriophage, Microbiology and Virology (EIBMV), Tbilisi, Georgia

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  • Thea Glonti,

    Affiliation: Eliava Institute of Bacteriophage, Microbiology and Virology (EIBMV), Tbilisi, Georgia

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  • Victor Krylov,

    Affiliation: Laboratory of Bacteriophage Genetics, State Institute for Genetics and Selection of Industrial Microorganisms (SIGSIM), Moscow, Russia

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  • Jan Mast,

    Affiliation: Unit Electron Microscopy, Veterinary and Agricultural Research Centre (VAR), Ukkel, Brussels, Belgium

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  • Luc Van Parys,

    Affiliation: Section Health of the Division Well-Being (Belgian Defence Staff), Queen Astrid Military Hospital, Neder-over-Heembeek, Brussels, Belgium

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  • Rob Lavigne,

    Affiliation: Laboratory of Gene Technology (LoGT), Katholieke Universiteit Leuven, Leuven, Belgium

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  • Guido Volckaert,

    Affiliation: Laboratory of Gene Technology (LoGT), Katholieke Universiteit Leuven, Leuven, Belgium

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  • Wesley Mattheus,

    Affiliation: Laboratory of Gene Technology (LoGT), Katholieke Universiteit Leuven, Leuven, Belgium

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  • Gunther Verween,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Peter De Corte,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Thomas Rose,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Serge Jennes,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Martin Zizi,

    Affiliations: Section Health of the Division Well-Being (Belgian Defence Staff), Queen Astrid Military Hospital, Neder-over-Heembeek, Brussels, Belgium, Department of Physiology (FYSP), Vrije Universiteit Brussel, Jette Brussels, Belgium

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  • Daniel De Vos,

    Affiliation: Laboratory for Molecular and Cellular Technology (LabMCT), Burn Centre, Queen Astrid Military Hospital, Bruynstraat, Neder-over-Heembeek, Brussels, Belgium

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  • Mario Vaneechoutte

    Affiliation: Laboratory of Bacteriology Research (LBR), Ghent University Hospital, Ghent, Belgium

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.pone.0004944

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