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Research Article

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

  • Fiona E. Lovegrove,

    Affiliation: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Noppadon Tangpukdee,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Robert O. Opoka,

    Affiliation: Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda

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  • Erin I. Lafferty,

    Affiliation: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Nimerta Rajwans,

    Affiliation: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Michael Hawkes,

    Affiliation: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada

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  • Srivicha Krudsood,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Sornchai Looareesuwan †,

    † Deceased.

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Chandy C. John,

    Affiliation: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • W. Conrad Liles equal contributor,

    equal contributor Contributed equally to this work with: W. Conrad Liles, Kevin C. Kain

    Affiliations: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Kevin C. Kain equal contributor mail

    equal contributor Contributed equally to this work with: W. Conrad Liles, Kevin C. Kain

    kevin.kain@uhn.on.ca

    Affiliations: McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.pone.0004912

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