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Research Article

Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain

  • Sharad P. Adekar,

    Affiliation: Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America

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  • Tsuyoshi Takahashi,

    Affiliation: Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • R. Mark Jones,

    Affiliation: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Fetweh H. Al-Saleem,

    Affiliation: Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Denise M. Ancharski,

    Affiliation: Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Michael J. Root,

    Affiliation: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • B. P. Kapadnis,

    Affiliation: Department of Microbiology, University of Pune, Pune, India

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  • Lance L. Simpson,

    Affiliation: Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Scott K. Dessain mail

    dessains@mlhs.org

    Affiliation: Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United States of America

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  • Published: August 20, 2008
  • DOI: 10.1371/journal.pone.0003023

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