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Research Article

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

  • Adriano Boasso mail,

    a.boasso@imperial.ac.uk

    Affiliations: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America, Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom

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  • Andrew W. Hardy,

    Affiliation: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    Current address: Vitae Pharmaceuticals, Ft. Washington, Pennsylvania, United States of America

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  • Stephanie A. Anderson,

    Affiliation: Henry M. Jackson Foundation, Infectious Disease Clinical Research Program (IDCRP), Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States of America

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  • Matthew J. Dolan,

    Affiliation: Henry M. Jackson Foundation, Infectious Disease Clinical research Program (IDCRP), San Antonio Military Medical Center (SAMMC), Fort Sam Houston, Texas, United States of America

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  • Gene M. Shearer

    Affiliation: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

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  • Published: August 13, 2008
  • DOI: 10.1371/journal.pone.0002961

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