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Research Article

Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to-Moderate Adherence Levels

  • Jean-Jacques Parienti mail,

    parienti-jj@chu-caen.fr

    Affiliations: Clinical Research and Biostatistics, and Infectious Diseases Departments, Côte de Nacre University Hospital, Caen, France, Pierre et Marie Curie University Paris 6, UMR S707 and INSERM U707, Paris, France

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  • Moupali Das-Douglas,

    Affiliation: Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, and The Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Véronique Massari,

    Affiliation: Pierre et Marie Curie University Paris 6, UMR S707 and INSERM U707, Paris, France

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  • David Guzman,

    Affiliation: Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, United States of America

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  • Steven G. Deeks,

    Affiliation: Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, and The Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Renaud Verdon,

    Affiliation: Clinical Research and Biostatistics, and Infectious Diseases Departments, Côte de Nacre University Hospital, Caen, France

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  • David R. Bangsberg

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, United States of America

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  • Published: July 30, 2008
  • DOI: 10.1371/journal.pone.0002783

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