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Research Article

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

  • Alison Wood-Kaczmar equal contributor,

    equal contributor Contributed equally to this work with: Alison Wood-Kaczmar, Sonia Gandhi

    Affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

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  • Sonia Gandhi equal contributor,

    equal contributor Contributed equally to this work with: Alison Wood-Kaczmar, Sonia Gandhi

    Affiliations: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom, Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom

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  • Zhi Yao,

    Affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

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  • Andrey S. Y. Abramov,

    Affiliation: Department of Physiology, University College London, London, United Kingdom

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  • Erik A. Miljan,

    Affiliation: ReNeuron Ltd, Guildford, United Kingdom

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  • Gregory Keen,

    Affiliation: Eisai London Research Laboratories Ltd, London, United Kingdom

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  • Lee Stanyer,

    Affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

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  • Iain Hargreaves,

    Affiliation: Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom

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  • Kristina Klupsch,

    Affiliation: Cancer Research United Kingdom, London, United Kingdom

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  • Emma Deas,

    Affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

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  • Julian Downward,

    Affiliation: Cancer Research United Kingdom, London, United Kingdom

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  • Louise Mansfield,

    Affiliation: Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

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  • Parmjit Jat,

    Affiliation: Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

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  • Joanne Taylor,

    Affiliation: Eisai London Research Laboratories Ltd, London, United Kingdom

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  • Simon Heales,

    Affiliations: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom, Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom

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  • Michael R. Duchen,

    Affiliation: Department of Physiology, University College London, London, United Kingdom

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  • David Latchman,

    Affiliations: Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom, Birkbeck, University of London, London, United Kingdom

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  • Sarah J. Tabrizi ,

    Affiliation: Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

    These authors also contributed equally to this work.

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  • Nicholas W. Wood mail

    n.wood@ion.ucl.ac.uk

    Affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

    These authors also contributed equally to this work.

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  • Published: June 18, 2008
  • DOI: 10.1371/journal.pone.0002455

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