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Research Article

Cathepsin K Null Mice Show Reduced Adiposity during the Rapid Accumulation of Fat Stores

  • Marcella Funicello,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Michela Novelli,

    Affiliation: Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology, University of Pisa, Pisa, Italy

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  • Maurizio Ragni,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Teresa Vottari,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Cesare Cocuzza,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Joaquin Soriano-Lopez,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Chiara Chiellini,

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Federico Boschi,

    Affiliation: Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, Medical Faculty, University of Verona, Verona, Italy

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  • Pasquina Marzola,

    Affiliation: Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, Medical Faculty, University of Verona, Verona, Italy

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  • Pellegrino Masiello,

    Affiliation: Department of Experimental Pathology, Medical Biotechnologies, Infectivology and Epidemiology, University of Pisa, Pisa, Italy

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  • Paul Saftig,

    Affiliation: Biochemical Institute, Christian-Albrechts University, Kiel, Germany

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  • Ferruccio Santini,

    Affiliation: Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Rene St-Jacques,

    Affiliation: Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada

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  • Sylvie Desmarais,

    Affiliation: Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada

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  • Nicolas Morin,

    Affiliation: Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada

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  • Joseph Mancini,

    Affiliation: Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada

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  • M. David Percival,

    Affiliation: Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada

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  • Aldo Pinchera,

    Affiliation: Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Margherita Maffei mail

    To whom correspondence should be addressed. E-mail: mmaffei@dti.telethon.it

    Affiliation: Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy

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  • Published: August 01, 2007
  • DOI: 10.1371/journal.pone.0000683

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