Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells

• Takashi Maejima ,

  Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

  Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Tsuyoshi Inoue ,

  Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

  Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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• Yasuharu Kanki,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Takahide Kohro,

  Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Guoliang Li,

  Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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• Yoshihiro Ohta,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Hiroshi Kimura ,

  * E-mail: hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

  Affiliation Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

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• Mika Kobayashi,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Akashi Taguchi,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Shuichi Tsutsumi,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Hiroko Iwanari,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Shogo Yamamoto,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Hirofumi Aruga,

  Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

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• Shoulian Dong,

  Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

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• Junko F. Stevens,

  Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

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• Huay Mei Poh,

  Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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• Kazuki Yamamoto,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Takeshi Kawamura,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Imari Mimura,

  Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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• Jun-ichi Suehiro,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Akira Sugiyama,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Kiyomi Kaneki,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Haruki Shibata,

  Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Yasunobu Yoshinaka,

  Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Takeshi Doi,

  Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Akimune Asanuma,

  Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Sohei Tanabe,

  Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

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• Toshiya Tanaka,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Takashi Minami,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Takao Hamakubo,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Juro Sakai,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Naohito Nozaki,

  Affiliation Mab Institute Inc., North Advancement Center for Science & Technology, Sapporo, Hokkaido, Japan

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• Hiroyuki Aburatani,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Masaomi Nangaku,

  Affiliation Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

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• Xiaoan Ruan,

  Affiliation Genome Institute of Singapore, Singapore, Singapore

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• Hideyuki Tanabe,

  Affiliation Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, Japan

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• Yijun Ruan,

  Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

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• Sigeo Ihara,

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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• Akira Endo,

  Affiliation Biopharm Research Laboratories, Inc., Koganei, Tokyo, Japan

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• Tatsuhiko Kodama ,

  * E-mail: hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

  Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

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•  [ ... ],
• Youichiro Wada

  * E-mail: hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

  Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Radioisotope Center, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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