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Structural Biology and Human Health: Medically Relevant Proteins from the SGC

Structural Biology and Human Health: Medically Relevant Proteins from the SGC.

This collection of articles represents some of the research highlights from the SGC (www.thesgc.org). The SGC is an international public-private partnership that determines three dimensional structures of medically important proteins from both humans and human parasites and places this information into the public domain, free from restrictions on use. The articles describe the structure and further characterisation of the proteins in an easily accessible way. All articles in this collection can be read on-line as interactive documents, where relevant features described in the text can be visualised as 3D molecular scenes that can be directly manipulated by the reader. New articles will be added to the Collection as they are published.

Image Credit: Wen Hwa Lee of the SGC.

 
 

Overviews

SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results

Wen Hwa Lee, Julián Atienza-Herrero, Ruben Abagyan, Brian D. Marsden

A New Method for Publishing Three-Dimensional Content

Eugene Raush, Max Totrov, Brian D. Marsden, Ruben Abagyan

 

Research Articles

Crystal Structure of the ATPase Domain of the Human AAA+ Protein Paraplegin/SPG7

Tobias Karlberg, Susanne van den Berg, Martin Hammarström, Johanna Sagemark, Ida Johansson, Lovisa Holmberg-Schiavone, Herwig Schüler

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

Alex N. Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee, Yasser El-Hawari, James E. Dunford, Grazyna Kochan, Vladimir Wsol, Hans-Joerg Martin, Edmund Maser, Udo Oppermann

Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

Yufeng Tong, Wolfram Tempel, Lyudmila Nedyalkova, Farrell MacKenzie, Hee-Won Park

Structural Studies of a Four-MBT Repeat Protein MBTD1

Jitka Eryilmaz, Patricia Pan, Maria F. Amaya, Abdellah Allali-Hassani, Aiping Dong, Melanie A. Adams-Cioaba, Farrell MacKenzie, Masoud Vedadi, Jinrong Min

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