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Research Article

General Theory for Integrated Analysis of Growth, Gene, and Protein Expression in Biofilms

  • Tianyu Zhang,

    Affiliation: Department of Mathematical Sciences, Montana State University, Bozeman, Montana, United States of America

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  • Breana Pabst,

    Affiliation: Department of Chemical and Biological Engineering, Montana State University, Bozeman, Montana, United States of America

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  • Isaac Klapper,

    Affiliation: Department of Mathematics, Temple University, Philadelphia, Pennsylvania, United States of America

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  • Philip S. Stewart mail

    phils@biofilm.montana.edu

    Affiliations: Department of Chemical and Biological Engineering, Montana State University, Bozeman, Montana, United States of America, Center for Biofilm Engineering, Montana State University, Bozeman, Montana, United States of America

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  • Published: December 23, 2013
  • DOI: 10.1371/journal.pone.0083626

About the Authors

Tianyu Zhang
Department of Mathematical Sciences, Montana State University, Bozeman, Montana, United States of America
Breana Pabst, Philip S. Stewart
Department of Chemical and Biological Engineering, Montana State University, Bozeman, Montana, United States of America
Isaac Klapper
Department of Mathematics, Temple University, Philadelphia, Pennsylvania, United States of America
Philip S. Stewart
Center for Biofilm Engineering, Montana State University, Bozeman, Montana, United States of America

Corresponding Author

Email: phils@biofilm.montana.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS. Performed the experiments: BP. Analyzed the data: PS BP. Contributed reagents/materials/analysis tools: BP. Wrote the paper: TZ PS. Conceived the basic model structure and identified case studies: PS. Formulated the mathematical model: TZ IK PS. Implemented numerical solution of the model case studies: TZ.