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Research Article

A Potential Role for Plasma Uric Acid in the Endothelial Pathology of Plasmodium falciparum malaria

  • Neida K. Mita-Mendoza,

    Affiliations: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America, Departmento de Biomedicina Molecular, Centro de Investigaciόn y Estudios Avanzados – Instituto Politécnico Nacional, Ciudad de México, México

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  • Diana L. van de Hoef,

    Affiliation: Department of Microbiology, Division of Parasitology, NYU School of Medicine, New York, New York, United States of America

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  • Tatiana M. Lopera-Mesa,

    Affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Saibou Doumbia,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali

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  • Drissa Konate,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali

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  • Mory Doumbouya,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali

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  • Wenjuan Gu,

    Affiliation: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Jennifer M. Anderson,

    Affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Leopoldo Santos-Argumedo,

    Affiliation: Departmento de Biomedicina Molecular, Centro de Investigaciόn y Estudios Avanzados – Instituto Politécnico Nacional, Ciudad de México, México

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  • Ana Rodriguez,

    Affiliation: Department of Microbiology, Division of Parasitology, NYU School of Medicine, New York, New York, United States of America

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  • Michael P. Fay,

    Affiliation: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Mahamadou Diakite,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali

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  • Carole A. Long,

    Affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Rick M. Fairhurst mail

    rfairhurst@niaid.nih.gov

    Affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Published: January 22, 2013
  • DOI: 10.1371/journal.pone.0054481

About the Authors

Neida K. Mita-Mendoza, Tatiana M. Lopera-Mesa, Jennifer M. Anderson, Carole A. Long, Rick M. Fairhurst
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
Neida K. Mita-Mendoza, Leopoldo Santos-Argumedo
Departmento de Biomedicina Molecular, Centro de Investigaciόn y Estudios Avanzados – Instituto Politécnico Nacional, Ciudad de México, México
Diana L. van de Hoef, Ana Rodriguez
Department of Microbiology, Division of Parasitology, NYU School of Medicine, New York, New York, United States of America
Saibou Doumbia, Drissa Konate, Mory Doumbouya, Mahamadou Diakite
Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odontostomatology, University of Bamako, Bamako, Mali
Wenjuan Gu, Michael P. Fay
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

Corresponding Author

Email: rfairhurst@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Collected clinical data: SD DK MD JMA MD. Conceived and designed the experiments: NKMM DLvdH TMLM JMA L SA AR MD CAL RMF. Performed the experiments: NKMM DLvdH TMLM. Analyzed the data: NKMM WG MPF RMF. Wrote the paper: NKMM MPF RMF.