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Research Article

Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals

  • Víctor Casanova equal contributor,

    equal contributor Contributed equally to this work with: Víctor Casanova, Isaac Naval-Macabuhay, Rafael Franco, Núria Climent, Peter J. McCormick

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    X
  • Isaac Naval-Macabuhay equal contributor,

    equal contributor Contributed equally to this work with: Víctor Casanova, Isaac Naval-Macabuhay, Rafael Franco, Núria Climent, Peter J. McCormick

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    X
  • Marta Massanella,

    Affiliation: Fundació irsiCaixa-HIVACAT, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain

    X
  • Marta Rodríguez-García,

    Affiliation: Department of Physiology and Neurobiology, Dartmouth Medical School Lebanon, Lebanon, New Hampshire, United States of America

    X
  • Julià Blanco,

    Affiliation: Fundació irsiCaixa-HIVACAT, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain

    X
  • José M. Gatell,

    Affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-AIDS Research Group, and Catalonian Center for HIV Vaccines (HIVACAT), Barcelona, Spain

    X
  • Felipe García,

    Affiliations: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-AIDS Research Group, and Catalonian Center for HIV Vaccines (HIVACAT), Barcelona, Spain, Infectious Diseases and AIDS Unit, Hospital Clínic de Barcelona, Barcelona, Spain

    X
  • Teresa Gallart,

    Affiliations: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-AIDS Research Group, and Catalonian Center for HIV Vaccines (HIVACAT), Barcelona, Spain, Service of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain

    X
  • Carme Lluis,

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

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  • Josefa Mallol,

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    X
  • Rafael Franco equal contributor,

    equal contributor Contributed equally to this work with: Víctor Casanova, Isaac Naval-Macabuhay, Rafael Franco, Núria Climent, Peter J. McCormick

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    Current address: Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain

    X
  • Núria Climent equal contributor,

    equal contributor Contributed equally to this work with: Víctor Casanova, Isaac Naval-Macabuhay, Rafael Franco, Núria Climent, Peter J. McCormick

    Affiliation: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-AIDS Research Group, and Catalonian Center for HIV Vaccines (HIVACAT), Barcelona, Spain

    X
  • Peter J. McCormick equal contributor mail

    equal contributor Contributed equally to this work with: Víctor Casanova, Isaac Naval-Macabuhay, Rafael Franco, Núria Climent, Peter J. McCormick

    pmccormick@ub.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    X
  • Published: December 11, 2012
  • DOI: 10.1371/journal.pone.0051287

About the Authors

Víctor Casanova, Isaac Naval-Macabuhay, Carme Lluis, Josefa Mallol, Rafael Franco, Peter J. McCormick
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
Marta Massanella, Julià Blanco
Fundació irsiCaixa-HIVACAT, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain
Marta Rodríguez-García
Department of Physiology and Neurobiology, Dartmouth Medical School Lebanon, Lebanon, New Hampshire, United States of America
José M. Gatell, Felipe García, Teresa Gallart, Núria Climent
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-AIDS Research Group, and Catalonian Center for HIV Vaccines (HIVACAT), Barcelona, Spain
Felipe García
Infectious Diseases and AIDS Unit, Hospital Clínic de Barcelona, Barcelona, Spain
Teresa Gallart
Service of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain

Corresponding Author

Email: pmccormick@ub.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VC INM MRG JB TG CL NC PJM. Performed the experiments: VC INM MRG MM. Analyzed the data: VC INM JB FG TG CL NC PJM. Contributed reagents/materials/analysis tools: JMG FG JB JM RF. Wrote the paper: VC CL PJM.