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Research Article

EGFR Gene Variants Are Associated with Specific Somatic Aberrations in Glioma

  • Carl Wibom mail,

    carl.wibom@onkologi.umu.se

    Affiliation: Department of Radiation Sciences, Oncology, Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden

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  • Soma Ghasimi,

    Affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

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  • Peter Van Loo,

    Affiliations: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton Cambridge, United Kingdom, Department of Human Genetics, VIB and KU Leuven, Leuven, Belgium

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  • Thomas Brännström,

    Affiliation: Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden

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  • Johan Trygg,

    Affiliation: Department of Chemistry, Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden

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  • Ching Lau,

    Affiliation: Department of Pediatrics and Hematology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Roger Henriksson,

    Affiliation: Department of Oncology, Karolinska Institute, Stockholm, Umeå, Sweden

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  • Tommy Bergenheim,

    Affiliation: Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden

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  • Ulrika Andersson,

    Affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

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  • Patrik Rydén,

    Affiliation: Computational Life Science Cluster (CLiC), Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden

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  • Beatrice Melin

    Affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

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  • Published: December 07, 2012
  • DOI: 10.1371/journal.pone.0047929

About the Authors

Carl Wibom
Department of Radiation Sciences, Oncology, Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden
Soma Ghasimi, Ulrika Andersson, Beatrice Melin
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
Peter Van Loo
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton Cambridge, United Kingdom
Thomas Brännström
Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden
Johan Trygg
Department of Chemistry, Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden
Ching Lau
Department of Pediatrics and Hematology, Baylor College of Medicine, Houston, Texas, United States of America
Roger Henriksson
Department of Oncology, Karolinska Institute, Stockholm, Umeå, Sweden
Tommy Bergenheim
Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
Patrik Rydén
Computational Life Science Cluster (CLiC), Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden
Peter Van Loo
Department of Human Genetics, VIB and KU Leuven, Leuven, Belgium

Corresponding Author

Email: carl.wibom@onkologi.umu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CW UA BM CL. Analyzed the data: CW PVL JT PR. Contributed reagents/materials/analysis tools: SG TB RH TB UA. Wrote the paper: CW PR BM. Critical revision: SG PVL TB JT RH TB UA PR BM CL.