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Research Article

African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts

  • Ching-Yu Cheng,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Saw Swee Hock School of Public Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore Eye Research Institute, Singapore, Singapore

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  • David Reich,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T., Cambridge, Massachusetts, United States of America

    X
  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Arti Tandon,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T., Cambridge, Massachusetts, United States of America

    X
  • Nick Patterson,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T., Cambridge, Massachusetts, United States of America

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  • Selvin Elizabeth,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Ermeg L. Akylbekova,

    Affiliation: Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America

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  • Frederick L. Brancati,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Josef Coresh,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Eric Boerwinkle,

    Affiliation: Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • David Altshuler,

    Affiliations: Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T., Cambridge, Massachusetts, United States of America, Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Herman A. Taylor,

    Affiliation: Jackson State University, Tougaloo College, and the University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • James G. Wilson,

    Affiliation: Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • W. H. Linda Kao mail

    wkao@jhsph.edu

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Published: March 16, 2012
  • DOI: 10.1371/journal.pone.0032840

About the Authors

Ching-Yu Cheng, Selvin Elizabeth, Frederick L. Brancati, Josef Coresh, W. H. Linda Kao
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America
Selvin Elizabeth, Frederick L. Brancati, Josef Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America
Frederick L. Brancati, W. H. Linda Kao
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
Ching-Yu Cheng
Saw Swee Hock School of Public Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Ching-Yu Cheng
Duke-NUS Graduate Medical School, Singapore, Singapore
Ching-Yu Cheng
Singapore Eye Research Institute, Singapore, Singapore
David Reich, Arti Tandon
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
David Altshuler
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Christopher A. Haiman, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
David Reich, Arti Tandon, Nick Patterson, David Altshuler
Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T., Cambridge, Massachusetts, United States of America
Ermeg L. Akylbekova
Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America
Eric Boerwinkle
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
David Altshuler
Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Herman A. Taylor
Jackson State University, Tougaloo College, and the University of Mississippi Medical Center, Jackson, Mississippi, United States of America
James G. Wilson
Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Corresponding Author

Email: wkao@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CYC DR CAH JW WHK. Performed the experiments: DR CAH EB JW. Analyzed the data: CYC AT NP. Contributed reagents/materials/analysis tools: DR CAH SE ELA FLB JC EB DA HAT BEH JW WHK. Wrote the paper: CYC DR WHK.