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Research Article

I-MOVE Multi-Centre Case Control Study 2010-11: Overall and Stratified Estimates of Influenza Vaccine Effectiveness in Europe

  • Esther Kissling mail,

    e.kissling@epiconcept.fr

    Affiliation: EpiConcept, Paris, France

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  • Marta Valenciano,

    Affiliation: EpiConcept, Paris, France

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  • Jean Marie Cohen,

    Affiliation: GROG/Open Rome, Paris, France

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  • Beatrix Oroszi,

    Affiliation: Office of the Chief Medical Officer, Budapest, Hungary

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  • Anne-Sophie Barret,

    Affiliations: Health Protection Surveillance Centre, Dublin, Ireland, European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden

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  • Caterina Rizzo,

    Affiliation: National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Roma, Italy

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  • Pawel Stefanoff,

    Affiliation: National Institute of Public Health, Warsaw, Poland

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  • Baltazar Nunes,

    Affiliation: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisbon, Portugal

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  • Daniela Pitigoi,

    Affiliations: National Institute of Research - Development for Microbiology and Immunology, Cantacuzino, Bucharest, Romania, University of Medicine and Pharmacy, Carol Davila, Bucharest, Romania

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  • Amparo Larrauri,

    Affiliation: National Centre for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain

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  • Isabelle Daviaud,

    Affiliation: GROG/Open Rome, Paris, France

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  • Judit Krisztina Horvath,

    Affiliation: National Center for Epidemiology, Budapest, Hungary

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  • Joan O'Donnell,

    Affiliation: Health Protection Surveillance Centre, Dublin, Ireland

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  • Thomas Seyler,

    Affiliations: EpiConcept, Paris, France, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Roma, Italy

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  • Iwona Anna Paradowska-Stankiewicz,

    Affiliation: National Institute of Public Health, Warsaw, Poland

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  • Pedro Pechirra,

    Affiliation: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisbon, Portugal

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  • Alina Elena Ivanciuc,

    Affiliation: National Institute of Research - Development for Microbiology and Immunology, Cantacuzino, Bucharest, Romania

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  • Silvia Jiménez-Jorge,

    Affiliation: National Centre for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain

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  • Camelia Savulescu,

    Affiliation: EpiConcept, Paris, France

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  • Bruno Christian Ciancio,

    Affiliation: European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

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  • Alain Moren

    Affiliation: EpiConcept, Paris, France

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  • Published: November 15, 2011
  • DOI: 10.1371/journal.pone.0027622

About the Authors

Esther Kissling, Marta Valenciano, Thomas Seyler, Camelia Savulescu, Alain Moren
EpiConcept, Paris, France
Jean Marie Cohen, Isabelle Daviaud
GROG/Open Rome, Paris, France
Beatrix Oroszi
Office of the Chief Medical Officer, Budapest, Hungary
Anne-Sophie Barret, Joan O'Donnell
Health Protection Surveillance Centre, Dublin, Ireland
Anne-Sophie Barret
European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden
Caterina Rizzo, Thomas Seyler
National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Roma, Italy
Pawel Stefanoff, Iwona Anna Paradowska-Stankiewicz
National Institute of Public Health, Warsaw, Poland
Baltazar Nunes, Pedro Pechirra
Instituto Nacional de Saúde Dr Ricardo Jorge, Lisbon, Portugal
Daniela Pitigoi, Alina Elena Ivanciuc
National Institute of Research - Development for Microbiology and Immunology, Cantacuzino, Bucharest, Romania
Daniela Pitigoi
University of Medicine and Pharmacy, Carol Davila, Bucharest, Romania
Amparo Larrauri, Silvia Jiménez-Jorge
National Centre for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Judit Krisztina Horvath
National Center for Epidemiology, Budapest, Hungary
Bruno Christian Ciancio
European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

Corresponding Author

Email: e.kissling@epiconcept.fr

Competing Interests

The authors have the following competing interest: E. Kissling, M. Valenciano, T. Seyler, C. Savulescu and A. Moren are employees of EpiConcept, Paris. J.M. Cohen and I. Daviaud are employees of GROG/Open Rome, Paris. As Head of Open Rome, J.M. Cohen is involved in several epidemiological studies that are partially or fully funded by pharmaceutical companies (Sanofi-Pasteur, GSK, Roche), nonprofit organizations (Mutuelles, Résaeu DES France) or public institutions (ECDC, CU Strasbourg). He is a member of Association Mieux Prescrire and the advisory boards of Novartis, Roche, and Wyeth (free participation, no compensation). During the past five years, he has received travel grants from Sanofi-Pasteur and Roche. I. Daviaud is involved, through the other institution with which she is affiliated and salaried (Open Rome research department), in the coordination or analysis of epidemiological studies partially or fully funded by Roche and GSK. EpiConcept conducted for the Mexican Social Security and GSK an evaluation of the Mexican hospital based surveillance system for intussusceptions (2008). EpiConcept coordinated studies for measuring influenza vaccine effectiveness funded by EVM, the association of the European Vaccine Manufacturers. None of the current authors were involved in these studies (2009). EpiConcept conducts for SP-MSD the data analysis of a study conducted in Finland to measure the impact of rotavirus vaccination on hospitalisation for acute gastroenteritis due to rotavirus infection (2009-10). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MV JMC CR BN DP AL JOD CS BCC AM. Performed the experiments: JMC BO ASB CR PS BN DP AL ID JKH JOD TS IAP-S PP AEI CS. Analyzed the data: EK MV AM. Participated in protocol writing: MV AM EK. Adapted GROG network database to I-MOVE design: JMC. Conceived the idea of a European network for monitoring influenza vaccine effectiveness: BCC. Wrote the first draft of the paper: EK MV. Contributed to the writing of the paper: EK MV JMC BO ASB CR PS BN DP AL ID JKH JOD TS IAP-S PP AEI SJ-J CS BCC AM.