Predicting the Tolerated Sequences for Proteins and Protein Interfaces Using RosettaBackrub Flexible Backbone Design

Colin A. Smith; Tanja Kortemme

doi:10.1371/journal.pone.0020451

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Open Access

Peer-reviewed

Research Article

Predicting the Tolerated Sequences for Proteins and Protein Interfaces Using RosettaBackrub Flexible Backbone Design

Colin A. Smith,

Affiliations Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
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Tanja Kortemme

* E-mail: kortemme@cgl.ucsf.edu

Affiliations Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
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Predicting the Tolerated Sequences for Proteins and Protein Interfaces Using RosettaBackrub Flexible Backbone Design

Colin A. Smith,
Tanja Kortemme

Published: July 18, 2011
https://doi.org/10.1371/journal.pone.0020451

About the Authors

Colin A. Smith

Affiliations Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Tanja Kortemme

* E-mail: kortemme@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAS TK. Performed the experiments: CAS. Analyzed the data: CAS. Contributed reagents/materials/analysis tools: CAS TK. Wrote the paper: CAS TK.

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Phage display
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Monte Carlo method
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Protein sequencing
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Crystal structure
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Protein folding
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Biochemical simulations
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Protein interactions
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Genetic algorithms
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