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Research Article

Low-Load High Volume Resistance Exercise Stimulates Muscle Protein Synthesis More Than High-Load Low Volume Resistance Exercise in Young Men

  • Nicholas A. Burd,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Daniel W. D. West,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Aaron W. Staples,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Philip J. Atherton,

    Affiliation: School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, United Kingdom

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  • Jeff M. Baker,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Daniel R. Moore,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Andrew M. Holwerda,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Gianni Parise,

    Affiliations: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada, Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Michael J. Rennie,

    Affiliation: School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, United Kingdom

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  • Steven K. Baker,

    Affiliation: Department of Neurology, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Stuart M. Phillips mail

    phillis@mcmaster.ca

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

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  • Published: August 09, 2010
  • DOI: 10.1371/journal.pone.0012033

About the Authors

Nicholas A. Burd, Daniel W. D. West, Aaron W. Staples, Jeff M. Baker, Daniel R. Moore, Andrew M. Holwerda, Gianni Parise, Stuart M. Phillips
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
Philip J. Atherton, Michael J. Rennie
School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, United Kingdom
Gianni Parise
Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada
Steven K. Baker
Department of Neurology, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: phillis@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAB DRM SMP. Performed the experiments: NAB DWDW AWS JMB DRM AMH SMP. Analyzed the data: NAB DWDW AWS PA JMB DRM AMH GP MJR SMP. Contributed reagents/materials/analysis tools: PA GP MJR SB SMP. Wrote the paper: NAB DWDW AWS PA JMB DRM AMH GP MJR SB SMP.