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Research Article

Calculation of the Free Energy and Cooperativity of Protein Folding

  • Alex Kentsis mail,

    To whom correspondence should be addressed. E-mail: alex.kentsis@childrens.harvard.edu.

    Affiliation: Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America

    Current address: Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Tatyana Gindin,

    Affiliation: Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America

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  • Mihaly Mezei,

    Affiliation: Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America

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  • Roman Osman

    Affiliation: Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America

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  • Published: May 16, 2007
  • DOI: 10.1371/journal.pone.0000446

About the Authors

Alex Kentsis, Tatyana Gindin, Mihaly Mezei, Roman Osman
Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, New York, United States of America

Corresponding Author

Email: alex.kentsis@childrens.harvard.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK RO. Performed the experiments: AK. Analyzed the data: AK TG MM. Contributed reagents/materials/analysis tools: AK. Wrote the paper: AK RO.