Bacterial Quorum Sensing Molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone Causes Direct Cytotoxicity and Reduced Cell Motility in Human Pancreatic Carcinoma Cells

Ashwath S. Kumar; Jeffrey N. Bryan; Senthil R. Kumar

doi:10.1371/journal.pone.0106480

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Peer-reviewed

Research Article

Bacterial Quorum Sensing Molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone Causes Direct Cytotoxicity and Reduced Cell Motility in Human Pancreatic Carcinoma Cells

Ashwath S. Kumar,

Affiliation Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America
⨯
Jeffrey N. Bryan,

Affiliation Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America
⨯
Senthil R. Kumar

* E-mail: kumars@missouri.edu

Affiliations Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America, Harry S. Truman Veterans Hospital, Columbia, Missouri, United States of America
⨯

Bacterial Quorum Sensing Molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone Causes Direct Cytotoxicity and Reduced Cell Motility in Human Pancreatic Carcinoma Cells

Ashwath S. Kumar,
Jeffrey N. Bryan,
Senthil R. Kumar

Published: September 4, 2014
https://doi.org/10.1371/journal.pone.0106480

About the Authors

Ashwath S. Kumar

Affiliation Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America

Jeffrey N. Bryan

Affiliation Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America

Senthil R. Kumar

* E-mail: kumars@missouri.edu

Affiliations Comparative Oncology and Epigenetics Laboratory, Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, United States of America, Harry S. Truman Veterans Hospital, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRK. Performed the experiments: SRK ASK. Analyzed the data: SRK ASK JNB. Contributed reagents/materials/analysis tools: SRK JNB. Wrote the paper: SRK JNB.

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