About the Authors

Keiichi Yamanaka

yamake@clin.medic.mie-u.ac.jp

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Takehisa Nakanishi

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Hiromitsu Saito

Affiliation Department of Animal Genomics, Functional Genomics Institute, Mie University Life Science Research Center, Tsu, Mie, Japan

Junko Maruyama

Affiliation Department of Clinical Engineering, Suzuka University of Medical Science, Suzuka, Mie, Japan

Kenichi Isoda

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Ayumu Yokochi

Affiliation Anesthesiology and Critical Care Medicine, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Kyoko Imanaka-Yoshida

Affiliations Pathology and Matrix Biology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan, Mie University Research Center for Matrix Biology, Tsu, Mie, Japan

Kenshiro Tsuda

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Masato Kakeda

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Ryuji Okamoto

Affiliation Cardiology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Satoshi Fujita

Affiliation Cardiology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Yoichiro Iwakura

Affiliation Division of Experimental Animal Immunology, Tokyo University of Science, Noda, Chiba, Japan

Noboru Suzuki

Affiliation Department of Animal Genomics, Functional Genomics Institute, Mie University Life Science Research Center, Tsu, Mie, Japan

Masaaki Ito

Affiliation Cardiology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Kazuo Maruyama

Affiliation Anesthesiology and Critical Care Medicine, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Esteban C. Gabazza

Affiliation Immunology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Toshimichi Yoshida

Affiliations Pathology and Matrix Biology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan, Mie University Research Center for Matrix Biology, Tsu, Mie, Japan

Motomu Shimaoka

Affiliation Molecular Pathology and Cell Adhesion Biology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Hitoshi Mizutani

Affiliation Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan

Competing Interests

Hitoshi Mizutani is an adviser of Oriental Yeast Co., which has commercial interest in the results of this research and technology (KCASP1Tg). The other authors declare no competing financial interests. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KY ECG TY MS HM. Performed the experiments: KY TN HS JM AY KI KT MK RO SF. Analyzed the data: KY TN HS JM KI AY KI-Y YI NS MI KM. Contributed reagents/materials/analysis tools: KY TN HS JM AY KI-Y KT MK RO SF. Contributed to the writing of the manuscript: KY ECG TY MS HM.