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Research Article

Application of Detergents or High Hydrostatic Pressure as Decellularization Processes in Uterine Tissues and Their Subsequent Effects on In Vivo Uterine Regeneration in Murine Models

  • Erna G. Santoso equal contributor,

    equal contributor Contributed equally to this work with: Erna G. Santoso, Keita Yoshida

    Affiliation: Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan

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  • Keita Yoshida equal contributor,

    equal contributor Contributed equally to this work with: Erna G. Santoso, Keita Yoshida

    Affiliation: Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan

    X
  • Yasushi Hirota,

    Affiliation: Department of Obstetrics and Gynecology, School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Masanori Aizawa,

    Affiliation: Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan

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  • Osamu Yoshino,

    Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan

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  • Akio Kishida,

    Affiliation: Department of Material-based Medical Engineering, Division of Biofunctional Restoration, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

    X
  • Yutaka Osuga,

    Affiliation: Department of Obstetrics and Gynecology, School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Shigeru Saito,

    Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan

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  • Takashi Ushida,

    Affiliations: Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan, Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan

    X
  • Katsuko S. Furukawa mail

    furukawa@mech.t.u-tokyo.ac.jp

    Affiliations: Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan, Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan

    X
  • Published: July 24, 2014
  • DOI: 10.1371/journal.pone.0103201

About the Authors

Erna G. Santoso, Keita Yoshida, Masanori Aizawa, Takashi Ushida, Katsuko S. Furukawa
Department of Mechanical Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan
Yasushi Hirota, Yutaka Osuga
Department of Obstetrics and Gynecology, School of Medicine, The University of Tokyo, Tokyo, Japan
Osamu Yoshino, Shigeru Saito
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
Akio Kishida
Department of Material-based Medical Engineering, Division of Biofunctional Restoration, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
Takashi Ushida, Katsuko S. Furukawa
Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan

Corresponding Author

Email: furukawa@mech.t.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EGS KY KSF. Performed the experiments: EGS KY MA YH KSF. Analyzed the data: EGS KY KSF. Contributed reagents/materials/analysis tools: YH AK KSF. Wrote the paper: EGS KY YH AK OY YO SS TU KSF.