About the Authors

Hiroyuki Toda

Affiliations Department of Psychiatry, National Defense Medical College, Tokorozawa, Japan, Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Shuken Boku

Affiliation Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, United States of America

Shin Nakagawa

snakaga@med.hokudai.ac.jp

Affiliation Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Takeshi Inoue

Affiliation Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Akiko Kato

Affiliation Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Naoki Takamura

Affiliation Pharmaceutical Laboratories, Dainippon Sumitomo Pharma Co. Ltd., Osaka, Japan

Ning Song

Affiliations Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan, Department of Psychiatry, The first hospital of China Medical University, Shenyang, China

Masashi Nibuya

Affiliation Department of Psychiatry, National Defense Medical College, Tokorozawa, Japan

Tsukasa Koyama

Affiliation Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Ichiro Kusumi

Affiliation Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Competing Interests

Hiroyuki Toda has received honoraria from GlaxoSmithKline, Pfizer, Astellas, Eli Lilly, Mochida Pharmaceutical, Otsuka Pharmaceutical, Meiji Seika Pharma, Shionogi, Janssen Pharmaceutical, and Yoshitomi Pharmaceutical. Shin Nakagawa has received honoraria from GlaxoSmithKline, Eisai, Pfizer, Daiichi-Sankyo, Meiji Seika Pharma, Ono Pharmaceutical, and Eli Lilly, and has received research/grant support from Pfizer, Eli Lilly, Eisai, and Ono Pharmaceutical. Takeshi Inoue has received honoraria from GlaxoSmithKline, Pfizer, Astellas, Eli Lilly, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, Otsuka Pharmaceutical, Meiji Seika Pharma, Asahi Kasei Pharma, Shionogi, Janssen Pharmaceutical, Takeda Pharmaceutical, and Yoshitomi Pharmaceutical; has received research/grant support from Otsuka Pharmaceutical; and is a member of the advisory boards of GlaxoSmithKline, Eli Lilly, Mochida Pharmaceutical, and Mitsubishi Tanabe Pharma. Tsukasa Koyama has received honoraria from GlaxoSmithKline, Astellas, and Eli Lilly; has received research/grant support from Astellas and GlaxoSmithKline; and is a member of the advisory boards of GlaxoSmithKline and Mitsubishi Tanabe Pharma. Dr. Ichiro Kusumi has received honoraria from Eli Lilly; has received research/grant support from Takeda Pharmaceutical, Astellas, and Dainippon Sumitomo Pharma; and is a member of the advisory board of Dainippon Sumitomo Pharma and Tanabe Mitsubishi Pharma. Shuken Boku and Akiko kato and Ning Song and Masashi Nibuya reported no conflicts of interest in this work. Naoki Takamura is employed by Dainippon Sumitomo Pharma. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HT SB SN TK. Performed the experiments: HT SB AK NT NS. Analyzed the data: HT AK. Wrote the paper: HT SB SN TI MN TK IK.