About the Authors

Deborah Amanda Goh

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Yanhong Dong

yanhong_dong@nuhs.edu.sg (YD); bswong@nus.edu.sg (BW)

Affiliations Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Memory Ageing and Cognition Centre (MACC), National University Health System (NUHS), Singapore, Singapore, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, The University of New South Wales, Sydney, New South Wales, Australia

Wah Yean Lee

Affiliations Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Memory Ageing and Cognition Centre (MACC), National University Health System (NUHS), Singapore, Singapore

Way Inn Koay

Affiliations Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Memory Ageing and Cognition Centre (MACC), National University Health System (NUHS), Singapore, Singapore

Stephen Ziyang Tay

Affiliations Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Memory Ageing and Cognition Centre (MACC), National University Health System (NUHS), Singapore, Singapore

Danny Soon

Affiliation Lilly-NUS Centre for Clinical Pharmacology, Singapore, Singapore

Christopher Chen

Affiliations Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Memory Ageing and Cognition Centre (MACC), National University Health System (NUHS), Singapore, Singapore

Claire Frances Brittain

Affiliation Lilly Erl Wood, Windlesham, Surrey, United Kingdom

Stephen Loucian Lowe

Affiliation Lilly-NUS Centre for Clinical Pharmacology, Singapore, Singapore

Boon-Seng Wong

yanhong_dong@nuhs.edu.sg (YD); bswong@nus.edu.sg (BW)

Affiliation Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Competing Interests

Drs. Danny Soon. Claire Brittain and Stephen Lowe are employees of Eli Lilly. While Eli Lilly did not provide direct financial support to this pilot study, the company did provide clinical facilities pertaining to subject screening, blood draws and neuropsychological assessments. This involvement does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BSW YD. Performed the experiments: DAG WYL WIK. Analyzed the data: DAG SZT CFB. Contributed reagents/materials/analysis tools: CC DS SLL. Wrote the paper: DAG BSW YHD SLL.